Effect of trans-cinnamic acid and p-coumaric acid on fibroblast motility: a pilot comparative study of in silico lipophilicity measure.
Rodrigo da Silva VianaFernanda Lima Torres de AquinoEmiliano BarretoPublished in: Natural product research (2020)
Cinnamic acids and their derivatives are found in abundance in fruits, vegetables, and other food products of plant origin. The trans-cinnamic and p-coumaric acids in particular have been a subject of research for the treatment of a diverse range of pathological conditions. However, it is unclear whether these derivatives exert a direct beneficial effect on the cells that play a role in regulating skin wound healing, such as fibroblasts. In this study, using in vitro scratch-wound healing assay, it was observed that treatment with trans-cinnamic acid resulted in increased migration of fibroblasts when compared with that of p-coumaric acid-treated cells, without any adverse effect on cell viability. Studies on the lipophilicity of these acids using the XLOGP3 algorithm showed that trans-cinnamic acid was more lipophilic than p-coumaric. Thus, the findings of this study indicated that the lipophilic characteristic of trans-cinnamic acid rendered it more suitable as a potential drug candidate.
Keyphrases
- wound healing
- induced apoptosis
- machine learning
- cell cycle arrest
- randomized controlled trial
- oxidative stress
- emergency department
- signaling pathway
- escherichia coli
- cell proliferation
- pseudomonas aeruginosa
- endoplasmic reticulum stress
- combination therapy
- drinking water
- anaerobic digestion
- electronic health record