ROS Induction Targets Persister Cancer Cells with Low Metabolic Activity in NRAS-Mutated Melanoma.
Ossia M EichhoffCorinne I StoffelJan KäslerLuzia BrikerPatrick TurkoGergely KarsaiNina ZilaVerena PaulitschkePhil Fang ChengAlexander LeitnerAndrea BileckNicola ZamboniAnja IrmischZsolt BalazsAizhan TastanovaSusana PascoalPål JohannsenRebekka WegmannJulien MenaAlaa OthmanVasanthi S ViswanathanJudith WenzinaAndrea AloiaAnnalisa SaltariAndreas Dzungnull nullRudolf AebersoldMelike AkFaisal S Al-QuaddoomiSilvana I AlbertJonas AlbinusIlaria AlborelliSonali AndaniPer-Olof AttingerMarina BacacDaniel BaumhoerBeatrice Beck-SchimmerNiko BeerenwinkelChristian BeiselLara BernasconiAnne BertoliniBernd BodenmillerXimena BonillaLars BosshardByron CalguaRuben CasanovaStéphane ChevrierNatalia ChicherovaRicardo CoelhoMaya D'CostaEsther DanenbergNatalie DavidsonMonica-Andreea DrãganReinhard DummerStefanie EnglerMartin ErkensKatja EschbachCinzia EspositoAndré FedierPedro FerreiraJoanna FicekAnja L FreiBruno FreySandra GoetzeLinda GrobGabriele GutDetlef GüntherMartina HabereckerPirmin HaeuptleViola Heinzelmann-SchwarzSylvia HerterRene HoltackersTamara HuesserAlexander ImmerAnja IrmischFrancis JacobAndrea JacobsTim M JaegerKatharina JahnAlva R JamesPhilip M JermannAndré KahlesAbdullah KahramanViktor H KoelzerWerner KueblerJack KuipersChristian P KunzeChristian KurzederKjong-Van LehmannMitchell LevesqueUlrike LischettiSebastian LugertGerd MaassMarkus G ManzPhilipp MarkolinMartin MehnertJulien MenaJulian M MetzlerNicola MiglinoEmanuela S MilaniHolger MochSimone MuenstRiccardo MurriCharlotte Ky NgStefan NicoletMarta NowakMonica Nunez LopezPatrick Ga PedrioliLucas PelkmansSalvatore PiscuoglioMichael PrummerNatalie RimmerMathilde RitterChristian RommelMaría L Rosano-GonzálezGunnar RätschNatascha SantacroceJacobo Sarabia Del CastilloRamona SchlenkerPetra C SchwalieSeverin SchwanTobias SchärGabriela SentiWenguang ShaoFranziska SingerSujana SivapathamBerend SnijderBettina SobottkaVipin T SreedharanStefan StarkDaniel J StekhovenTanmay TannaAlexandre Pa TheocharidesTinu M ThomasMarkus TolnayVinko TosevskiNora C ToussaintMustafa A TuncelMarina TusupAudrey Van DrogenMarcus VetterTatjana VlajnicSandra WeberWalter P WeberRebekka WegmannMichael WellerFabian WendtNorbert WeyAndreas WickiMattheus He WildschutBernd WollscheidShuqing YuJohanna ZieglerMarc ZimmermannMartin ZocheGregor ZuendMichael KrauthammerStuart L SchreiberThorsten HornemannMartin DistelBerend SnijderReinhard DummerMitchell Paul LevesquePublished in: Cancer research (2023)
Metabolic reprogramming in drug-resistant NRAS-mutated melanoma cells confers sensitivity to ROS induction, which suppresses tumor growth and metastasis in combination with MAPK pathway inhibitors.