Alexander Leitner

Scopus Author ID ORCID

Publication Activity (10 Years)

Years Active: 2016-2024
Publications (10 Years): 62

Top Venues

Nature communications

Nature structural & molecular biology

EMBO reports

Proceedings of the National Academy of Sciences of the United States of America

ETH Zürich

University of Vienna (PHD)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

ETH Zürich

Switzerland

Senior Scientist / Principal Investigator :: Institute of Molecular Systems Biology

Education History

University of Vienna

Austria

PHD :: Institute of Analytical Chemistry

University of Vienna

Austria

MSC :: Institute of Analytical Chemistry

Publications

Junsun Park, Hyunmin Kim, Daniel Gestaut, Seyeon Lim, Kwadwo A Opoku-Nsiah, Alexander Leitner, Judith Frydman, Soung Hun Roh
A structural vista of phosducin-like PhLP2A-chaperonin TRiC cooperation during the ATP-driven folding cycle. Nature communications 15 (1) (2024)
Basavraj Khanppnavar, Dina Schuster, Pia Lavriha, Federico Uliana, Merve Özel, Ved Mehta, Alexander Leitner, Paola Picotti, Volodymyr M Korkhov
Regulatory sites of CaM-sensitive adenylyl cyclase AC8 revealed by cryo-EM and structural proteomics. EMBO reports (2024)
Basavraj Khanppnavar, Dina Schuster, Pia Lavriha, Federico Uliana, Merve Özel, Ved Mehta, Alexander Leitner, Paola Picotti, Volodymyr M Korkhov
Regulatory sites of CaM-sensitive adenylyl cyclase AC8 revealed by cryo-EM and structural proteomics. EMBO reports (2024)
Tebbe de Vries, Mihajlo Novakovic, Yinan Ni, Izabela Smok, Clara Inghelram, Maria Bikaki, Chris P Sarnowski, Yaning Han, Leonidas Emmanouilidis, Giacomo Padroni, Alexander Leitner, Frédéric Hai-Trieu Allain
Specific protein-RNA interactions are mostly preserved in biomolecular condensates. Science advances 10 (10) (2024)
Colin W Combe, Lars Kolbowski, Lutz Fischer, Ville Koskinen, Joshua A Klein, Alexander Leitner, Andrew R Jones, Juan Antonio Vizcaino, Juri Rappsilber
mzIdentML 1.3.0 - Essential progress on the support of crosslinking and other identifications based on multiple spectra. Proteomics (2024)
Tebbe de Vries, Mihajlo Novakovic, Yinan Ni, Izabela Smok, Clara Inghelram, Maria Bikaki, Chris P Sarnowski, Yaning Han, Leonidas Emmanouilidis, Giacomo Padroni, Alexander Leitner, Frédéric Hai-Trieu Allain
Specific protein-RNA interactions are mostly preserved in biomolecular condensates. Science advances 10 (10) (2024)
Junsun Park, Hyunmin Kim, Daniel Gestaut, Seyeon Lim, Kwadwo A Opoku-Nsiah, Alexander Leitner, Judith Frydman, Soung Hun Roh
A structural vista of phosducin-like PhLP2A-chaperonin TRiC cooperation during the ATP-driven folding cycle. Nature communications 15 (1) (2024)
Basavraj Khanppnavar, Dina Schuster, Pia Lavriha, Federico Uliana, Merve Özel, Ved Mehta, Alexander Leitner, Paola Picotti, Volodymyr M Korkhov
Regulatory sites of CaM-sensitive adenylyl cyclase AC8 revealed by cryo-EM and structural proteomics. EMBO reports 25 (3) (2024)
Rafal Zdanowicz, Pavel Afanasyev, Adam Pruška, Julian A Harrison, Christoph Giese, Daniel Boehringer, Alexander Leitner, Renato Zenobi, Rudi Glockshuber
Stoichiometry and architecture of the human pyruvate dehydrogenase complex. Science advances 10 (29) (2024)
Basavraj Khanppnavar, Dina Schuster, Pia Lavriha, Federico Uliana, Merve Özel, Ved Mehta, Alexander Leitner, Paola Picotti, Volodymyr M Korkhov
Regulatory sites of CaM-sensitive adenylyl cyclase AC8 revealed by cryo-EM and structural proteomics. EMBO reports 25 (3) (2024)
Basavraj Khanppnavar, Dina Schuster, Pia Lavriha, Federico Uliana, Merve Özel, Ved Mehta, Alexander Leitner, Paola Picotti, Volodymyr M Korkhov
Regulatory sites of CaM-sensitive adenylyl cyclase AC8 revealed by cryo-EM and structural proteomics. EMBO reports 25 (3) (2024)
Junsun Park, Hyunmin Kim, Daniel Gestaut, Seyeon Lim, Kwadwo A Opoku-Nsiah, Alexander Leitner, Judith Frydman, Soung Hun Roh
A structural vista of phosducin-like PhLP2A-chaperonin TRiC cooperation during the ATP-driven folding cycle. Nature communications 15 (1) (2024)
Rafal Zdanowicz, Pavel Afanasyev, Adam Pruška, Julian A Harrison, Christoph Giese, Daniel Boehringer, Alexander Leitner, Renato Zenobi, Rudi Glockshuber
Stoichiometry and architecture of the human pyruvate dehydrogenase complex. Science advances 10 (29) (2024)
Junsun Park, Hyunmin Kim, Daniel Gestaut, Seyeon Lim, Kwadwo A Opoku-Nsiah, Alexander Leitner, Judith Frydman, Soung Hun Roh
A structural vista of phosducin-like PhLP2A-chaperonin TRiC cooperation during the ATP-driven folding cycle. Nature communications 15 (1) (2024)
David Francis Burke, Patrick Bryant, Inigo Barrio-Hernandez, Danish Memon, Gabriele Pozzati, Aditi Shenoy, Wensi Zhu, Alistair S Dunham, Pascal Albanese, Andrew Keller, Richard A Scheltema, James E Bruce, Alexander Leitner, Petras J Kundrotas, Pedro Beltrao, Arne Elofsson
Towards a structurally resolved human protein interaction network. Nature structural & molecular biology 30 (2) (2023)
Karolina Pavic, Nikhil Gupta, Judit Domènech Omella, Rita Derua, Anna Aakula, Riikka Huhtaniemi, Juha A Määttä, Nico Höfflin, Juha Okkeri, Zhizhi Wang, Otto Kauko, Roosa Varjus, Henrik Honkanen, Daniel Kwaku Abankwa, Maja Köhn, Vesa Pekka Hytönen, Wenqing Xu, Jakob Nilsson, Rebecca Page, Veerle Janssens, Alexander Leitner, Jukka Westermarck
Structural mechanism for inhibition of PP2A-B56α and oncogenicity by CIP2A. Nature communications 14 (1) (2023)
Ossia M Eichhoff, Corinne I Stoffel, Jan Käsler, Luzia Briker, Patrick Turko, Gergely Karsai, Nina Zila, Verena Paulitschke, Phil Fang Cheng, Alexander Leitner, Andrea Bileck, Nicola Zamboni, Anja Irmisch, Zsolt Balazs, Aizhan Tastanova, Susana Pascoal, Pål Johannsen, Rebekka Wegmann, Julien Mena, Alaa Othman, Vasanthi S Viswanathan, Judith Wenzina, Andrea Aloia, Annalisa Saltari, Andreas Dzung, null null, Rudolf Aebersold, Melike Ak, Faisal S Al-Quaddoomi, Silvana I Albert, Jonas Albinus, Ilaria Alborelli, Sonali Andani, Per-Olof Attinger, Marina Bacac, Daniel Baumhoer, Beatrice Beck-Schimmer, Niko Beerenwinkel, Christian Beisel, Lara Bernasconi, Anne Bertolini, Bernd Bodenmiller, Ximena Bonilla, Lars Bosshard, Byron Calgua, Ruben Casanova, Stéphane Chevrier, Natalia Chicherova, Ricardo Coelho, Maya D'Costa, Esther Danenberg, Natalie Davidson, Monica-Andreea Drãgan, Reinhard Dummer, Stefanie Engler, Martin Erkens, Katja Eschbach, Cinzia Esposito, André Fedier, Pedro Ferreira, Joanna Ficek, Anja L Frei, Bruno Frey, Sandra Goetze, Linda Grob, Gabriele Gut, Detlef Günther, Martina Haberecker, Pirmin Haeuptle, Viola Heinzelmann-Schwarz, Sylvia Herter, Rene Holtackers, Tamara Huesser, Alexander Immer, Anja Irmisch, Francis Jacob, Andrea Jacobs, Tim M Jaeger, Katharina Jahn, Alva R James, Philip M Jermann, André Kahles, Abdullah Kahraman, Viktor H Koelzer, Werner Kuebler, Jack Kuipers, Christian P Kunze, Christian Kurzeder, Kjong-Van Lehmann, Mitchell Levesque, Ulrike Lischetti, Sebastian Lugert, Gerd Maass, Markus G Manz, Philipp Markolin, Martin Mehnert, Julien Mena, Julian M Metzler, Nicola Miglino, Emanuela S Milani, Holger Moch, Simone Muenst, Riccardo Murri, Charlotte Ky Ng, Stefan Nicolet, Marta Nowak, Monica Nunez Lopez, Patrick Ga Pedrioli, Lucas Pelkmans, Salvatore Piscuoglio, Michael Prummer, Natalie Rimmer, Mathilde Ritter, Christian Rommel, María L Rosano-González, Gunnar Rätsch, Natascha Santacroce, Jacobo Sarabia Del Castillo, Ramona Schlenker, Petra C Schwalie, Severin Schwan, Tobias Schär, Gabriela Senti, Wenguang Shao, Franziska Singer, Sujana Sivapatham, Berend Snijder, Bettina Sobottka, Vipin T Sreedharan, Stefan Stark, Daniel J Stekhoven, Tanmay Tanna, Alexandre Pa Theocharides, Tinu M Thomas, Markus Tolnay, Vinko Tosevski, Nora C Toussaint, Mustafa A Tuncel, Marina Tusup, Audrey Van Drogen, Marcus Vetter, Tatjana Vlajnic, Sandra Weber, Walter P Weber, Rebekka Wegmann, Michael Weller, Fabian Wendt, Norbert Wey, Andreas Wicki, Mattheus He Wildschut, Bernd Wollscheid, Shuqing Yu, Johanna Ziegler, Marc Zimmermann, Martin Zoche, Gregor Zuend, Michael Krauthammer, Stuart L Schreiber, Thorsten Hornemann, Martin Distel, Berend Snijder, Reinhard Dummer, Mitchell Paul Levesque
ROS Induction Targets Persister Cancer Cells with Low Metabolic Activity in NRAS-Mutated Melanoma. Cancer research (2023)
Karolina Pavic, Nikhil Gupta, Judit Domènech Omella, Rita Derua, Anna Aakula, Riikka Huhtaniemi, Juha A Määttä, Nico Höfflin, Juha Okkeri, Zhizhi Wang, Otto Kauko, Roosa Varjus, Henrik Honkanen, Daniel Kwaku Abankwa, Maja Köhn, Vesa Pekka Hytönen, Wenqing Xu, Jakob Nilsson, Rebecca Page, Veerle Janssens, Alexander Leitner, Jukka Westermarck
Structural mechanism for inhibition of PP2A-B56α and oncogenicity by CIP2A. Nature communications 14 (1) (2023)
Benjamin Steinmetz, Izabela Smok, Maria Bikaki, Alexander Leitner
Protein-RNA interactions: from mass spectrometry to drug discovery. Essays in biochemistry (2023)
David Francis Burke, Patrick Bryant, Inigo Barrio-Hernandez, Danish Memon, Gabriele Pozzati, Aditi Shenoy, Wensi Zhu, Alistair S Dunham, Pascal Albanese, Andrew Keller, Richard A Scheltema, James E Bruce, Alexander Leitner, Petras J Kundrotas, Pedro Beltrao, Arne Elofsson
Towards a structurally resolved human protein interaction network. Nature structural & molecular biology 30 (2) (2023)
David Francis Burke, Patrick Bryant, Inigo Barrio-Hernandez, Danish Memon, Gabriele Pozzati, Aditi Shenoy, Wensi Zhu, Alistair S Dunham, Pascal Albanese, Andrew Keller, Richard A Scheltema, James E Bruce, Alexander Leitner, Petras J Kundrotas, Pedro Beltrao, Arne Elofsson
Towards a structurally resolved human protein interaction network. Nature structural & molecular biology (2023)
Karolina Pavic, Nikhil Gupta, Judit Domènech Omella, Rita Derua, Anna Aakula, Riikka Huhtaniemi, Juha A Määttä, Nico Höfflin, Juha Okkeri, Zhizhi Wang, Otto Kauko, Roosa Varjus, Henrik Honkanen, Daniel Kwaku Abankwa, Maja Köhn, Vesa Pekka Hytönen, Wenqing Xu, Jakob Nilsson, Rebecca Page, Veerle Janssens, Alexander Leitner, Jukka Westermarck
Structural mechanism for inhibition of PP2A-B56α and oncogenicity by CIP2A. Nature communications 14 (1) (2023)
Jann-Louis Hau, Susann Kaltwasser, Valentin Muras, Marco S Casutt, Georg Vohl, Björn Claußen, Wojtek Steffen, Alexander Leitner, Eckhard Bill, George E Cutsail, Serena DeBeer, Janet Vonck, Julia Steuber, Güenter Fritz
Conformational coupling of redox-driven Na + -translocation in Vibrio cholerae NADH:quinone oxidoreductase. Nature structural & molecular biology (2023)
Karolina Pavic, Nikhil Gupta, Judit Domènech Omella, Rita Derua, Anna Aakula, Riikka Huhtaniemi, Juha A Määttä, Nico Höfflin, Juha Okkeri, Zhizhi Wang, Otto Kauko, Roosa Varjus, Henrik Honkanen, Daniel Kwaku Abankwa, Maja Köhn, Vesa Pekka Hytönen, Wenqing Xu, Jakob Nilsson, Rebecca Page, Veerle Janssens, Alexander Leitner, Jukka Westermarck
Structural mechanism for inhibition of PP2A-B56α and oncogenicity by CIP2A. Nature communications 14 (1) (2023)
Nina Zila, Ossia M Eichhoff, Irene Steiner, Thomas Mohr, Andrea Bileck, Phil Fang Cheng, Alexander Leitner, Ludovic C J Gillet, Tatjana Sajic, Sandra Goetze, Betty Friedrich, Patricia Bortel, Johanna Strobl, René Reitermaier, Sabrina A Hogan, Julia Martínez Gómez, Ramon Staeger, Felix Tuchmann, Sophie Peters, Georg Stary, Mario Kuttke, Adelheid Elbe-Buerger, Christoph Hoeller, Rainer Kunstfeld, Wolfgang Weninger, Bernd Wollscheid, Reinhard Dummer, Lars Einar French, Christopher Gerner, Ruedi Aebersold, Mitchell Paul Levesque, Verena Paulitschke
Proteomic profiling of advanced melanoma patients to predict therapeutic response to anti-PD-1 therapy. Clinical cancer research : an official journal of the American Association for Cancer Research (2023)
Karolina Pavic, Nikhil Gupta, Judit Domènech Omella, Rita Derua, Anna Aakula, Riikka Huhtaniemi, Juha A Määttä, Nico Höfflin, Juha Okkeri, Zhizhi Wang, Otto Kauko, Roosa Varjus, Henrik Honkanen, Daniel Kwaku Abankwa, Maja Köhn, Vesa Pekka Hytönen, Wenqing Xu, Jakob Nilsson, Rebecca Page, Veerle Janssens, Alexander Leitner, Jukka Westermarck
Structural mechanism for inhibition of PP2A-B56α and oncogenicity by CIP2A. Nature communications 14 (1) (2023)
Carina Kern, Christin Radon, Wolfgang Wende, Alexander Leitner, Katja Sträβer
Cross-linking mass spectrometric analysis of the endogenous TREX complex from S. cerevisiae. RNA (New York, N.Y.) (2023)
David Francis Burke, Patrick Bryant, Inigo Barrio-Hernandez, Danish Memon, Gabriele Pozzati, Aditi Shenoy, Wensi Zhu, Alistair S Dunham, Pascal Albanese, Andrew Keller, Richard A Scheltema, James E Bruce, Alexander Leitner, Petras J Kundrotas, Pedro Beltrao, Arne Elofsson
Towards a structurally resolved human protein interaction network. Nature structural & molecular biology 30 (2) (2023)
Diane C A Barret, Dina Schuster, Matthew J Rodrigues, Alexander Leitner, Paola Picotti, Gebhard F X Schertler, U Benjamin Kaupp, Volodymyr M Korkhov, Jacopo Marino
Structural basis of calmodulin modulation of the rod cyclic nucleotide-gated channel. Proceedings of the National Academy of Sciences of the United States of America 120 (15) (2023)
Ossia M Eichhoff, Corinne I Stoffel, Jan Käsler, Luzia Briker, Patrick Turko, Gergely Karsai, Nina Zila, Verena Paulitschke, Phil Fang Cheng, Alexander Leitner, Andrea Bileck, Nicola Zamboni, Anja Irmisch, Zsolt Balazs, Aizhan Tastanova, Susana Pascoal, Pål Johannsen, Rebekka Wegmann, Julien Mena, Alaa Othman, Vasanthi S Viswanathan, Judith Wenzina, Andrea Aloia, Annalisa Saltari, Andreas Dzung, null null, Michael Krauthammer, Stuart L Schreiber, Thorsten Hornemann, Martin Distel, Berend Snijder, Reinhard Dummer, Mitchell Paul Levesque
ROS Induction Targets Persister Cancer Cells with Low Metabolic Activity in NRAS-Mutated Melanoma. Cancer research (2023)
David Francis Burke, Patrick Bryant, Inigo Barrio-Hernandez, Danish Memon, Gabriele Pozzati, Aditi Shenoy, Wensi Zhu, Alistair S Dunham, Pascal Albanese, Andrew Keller, Richard A Scheltema, James E Bruce, Alexander Leitner, Petras J Kundrotas, Pedro Beltrao, Arne Elofsson
Towards a structurally resolved human protein interaction network. Nature structural & molecular biology 30 (2) (2023)
Chris P Sarnowski, Michael Götze, Alexander Leitner
RNxQuest : An Extension to the xQuest Pipeline Enabling Analysis of Protein-RNA Cross-Linking/Mass Spectrometry Data. Journal of proteome research (2023)
David Francis Burke, Patrick Bryant, Inigo Barrio-Hernandez, Danish Memon, Gabriele Pozzati, Aditi Shenoy, Wensi Zhu, Alistair S Dunham, Pascal Albanese, Andrew Keller, Richard A Scheltema, James E Bruce, Alexander Leitner, Petras J Kundrotas, Pedro Beltrao, Arne Elofsson
Towards a structurally resolved human protein interaction network. Nature structural & molecular biology (2023)
Georg Dorn, Christoph Gmeiner, Tebbe de Vries, Emil Dedic, Mihajlo Novakovic, Fred F Damberger, Christophe Maris, Esteban Finol, Chris P Sarnowski, Joachim Kohlbrecher, Timothy J Welsh, Sreenath Bolisetty, Raffaele Mezzenga, Ruedi Aebersold, Alexander Leitner, Maxim Yulikov, Gunnar Jeschke, Frédéric Hai-Trieu Allain
Integrative solution structure of PTBP1-IRES complex reveals strong compaction and ordering with residual conformational flexibility. Nature communications 14 (1) (2023)
David Francis Burke, Patrick Bryant, Inigo Barrio-Hernandez, Danish Memon, Gabriele Pozzati, Aditi Shenoy, Wensi Zhu, Alistair S Dunham, Pascal Albanese, Andrew Keller, Richard A Scheltema, James E Bruce, Alexander Leitner, Petras J Kundrotas, Pedro Beltrao, Arne Elofsson
Towards a structurally resolved human protein interaction network. Nature structural & molecular biology 30 (2) (2023)
David Francis Burke, Patrick Bryant, Inigo Barrio-Hernandez, Danish Memon, Gabriele Pozzati, Aditi Shenoy, Wensi Zhu, Alistair S Dunham, Pascal Albanese, Andrew Keller, Richard A Scheltema, James E Bruce, Alexander Leitner, Petras J Kundrotas, Pedro Beltrao, Arne Elofsson
Towards a structurally resolved human protein interaction network. Nature structural & molecular biology 30 (2) (2023)
David Francis Burke, Patrick Bryant, Inigo Barrio-Hernandez, Danish Memon, Gabriele Pozzati, Aditi Shenoy, Wensi Zhu, Alistair S Dunham, Pascal Albanese, Andrew Keller, Richard A Scheltema, James E Bruce, Alexander Leitner, Petras J Kundrotas, Pedro Beltrao, Arne Elofsson
Towards a structurally resolved human protein interaction network. Nature structural & molecular biology 30 (2) (2023)
David Francis Burke, Patrick Bryant, Inigo Barrio-Hernandez, Danish Memon, Gabriele Pozzati, Aditi Shenoy, Wensi Zhu, Alistair S Dunham, Pascal Albanese, Andrew Keller, Richard A Scheltema, James E Bruce, Alexander Leitner, Petras J Kundrotas, Pedro Beltrao, Arne Elofsson
Towards a structurally resolved human protein interaction network. Nature structural & molecular biology 30 (2) (2023)
Anna Knörlein, Chris P Sarnowski, Tebbe de Vries, Moritz Stoltz, Michael Götze, Ruedi Aebersold, Frédéric Hai-Trieu Allain, Alexander Leitner, Jonathan Hall
Nucleotide-amino acid π-stacking interactions initiate photo cross-linking in RNA-protein complexes. Nature communications 13 (1) (2022)
Tebbe de Vries, William Martelly, Sébastien Campagne, Kevin Sabath, Chris P Sarnowski, Jason Wong, Alexander Leitner, Stefanie Jonas, Shalini Sharma, Frédéric Hai-Trieu Allain
Sequence-specific RNA recognition by an RGG motif connects U1 and U2 snRNP for spliceosome assembly. Proceedings of the National Academy of Sciences of the United States of America 119 (6) (2022)
Alexander Leitner
Probing the secrets of probes. Nature chemical biology 18 (8) (2022)
Vladyslava Gorbovytska, Seung-Kyoon Kim, Filiz Kuybu, Michael Götze, Dahun Um, Keunsoo Kang, Andreas Pittroff, Theresia Brennecke, Lisa-Marie Schneider, Alexander Leitner, Tae-Kyung Kim, Claus-D Kuhn
Enhancer RNAs stimulate Pol II pause release by harnessing multivalent interactions to NELF. Nature communications 13 (1) (2022)
Jonathan J Knowlton, Daniel Gestaut, Boxue Ma, Gwen M Taylor, Alpay Burak Seven, Alexander Leitner, Gregory J Wilson, Sreejesh Shanker, Nathan A Yates, B V Venkataram Prasad, Ruedi Aebersold, Wah Chiu, Judith Frydman, Terence S Dermody
Structural and functional dissection of reovirus capsid folding and assembly by the prefoldin-TRiC/CCT chaperone network. Proceedings of the National Academy of Sciences of the United States of America 118 (11) (2021)
Esben Trabjerg, Arend Keller, Alexander Leitner
pH Dependence of Succinimide-Ester-Based Protein Cross-Linking for Structural Mass Spectrometry Applications. ACS measurement science au 2 (2) (2021)
Weaam I Mohamed, Sophia L Park, Julius Rabl, Alexander Leitner, Daniel Boehringer, Matthias Peter
The human GID complex engages two independent modules for substrate recruitment. EMBO reports 22 (11) (2021)
Esben Trabjerg, Arend Keller, Alexander Leitner
pH Dependence of Succinimide-Ester-Based Protein Cross-Linking for Structural Mass Spectrometry Applications. ACS measurement science au 2 (2) (2021)
Stefan Gerhardy, Michaela Oborská-Oplová, Ludovic C J Gillet, Richard Börner, Rob W van Nues, Alexander Leitner, Erich Michel, Janusz Jurand Petkowski, Sander Granneman, Roland K O Sigel, Ruedi Aebersold, Vikram Govind Panse
Puf6 primes 60S pre-ribosome nuclear export at low temperature. Nature communications 12 (1) (2021)
Marc Kschonsak, Han Chow Chua, Claudia Weidling, Nourdine Chakouri, Cameron L Noland, Katharina Schott, Timothy Chang, Christine Tam, Nidhi Patel, Christopher P Arthur, Alexander Leitner, Manu Ben-Johny, Claudio Ciferri, Stephan Alexander Pless, Jian Payandeh
Structural architecture of the human NALCN channelosome. Nature 603 (7899) (2021)
Michael Götze, Chris P Sarnowski, Tebbe de Vries, Anna Knörlein, Frédéric H-T Allain, Jonathan Hall, Ruedi Aebersold, Alexander Leitner
Single Nucleotide Resolution RNA-Protein Cross-Linking Mass Spectrometry: A Simple Extension of the CLIR-MS Workflow. Analytical chemistry 93 (44) (2021)
Azadeh Mohammadi, Aline Tschanz, Alexander Leitner
Expanding the Cross-Link Coverage of a Carboxyl-Group Specific Chemical Cross-Linking Strategy for Structural Proteomics Applications. Analytical chemistry 93 (4) (2021)
Felix Klatt, Alexander Leitner, Iana V Kim, Hung Ho-Xuan, Elisabeth V Schneider, Franziska Langhammer, Robin Weinmann, Melanie R Müller, Robert Huber, Gunter Meister, Claus-D Kuhn
A precisely positioned MED12 activation helix stimulates CDK8 kinase activity. Proceedings of the National Academy of Sciences of the United States of America 117 (6) (2020)
Emiliya Poghosyan, Ioan Iacovache, Lenka Faltova, Alexander Leitner, Pinfen Yang, Dennis R Diener, Ruedi Aebersold, Benoit Zuber, Takashi Ishikawa
The structure and symmetry of the radial spoke protein complex in Chlamydomonas flagella. Journal of cell science 133 (16) (2020)
Kevin Sabath, Melanie L Stäubli, Sabrina Marti, Alexander Leitner, Murielle Moes, Stefanie Jonas
INTS10-INTS13-INTS14 form a functional module of Integrator that binds nucleic acids and the cleavage module. Nature communications 11 (1) (2020)
Martin Saurer, David J F Ramrath, Moritz Niemann, Salvatore Calderaro, Céline Prange, Simone Mattei, Alain Scaiola, Alexander Leitner, Philipp Bieri, Elke K Horn, Marc Leibundgut, Daniel Boehringer, Andre Schneider, Nenad Ban
Mitoribosomal small subunit biogenesis in trypanosomes involves an extensive assembly machinery. Science (New York, N.Y.) 365 (6458) (2020)
Harshul Arora Verasztó, Maria Logotheti, Reinhard Albrecht, Alexander Leitner, Hongbo Zhu, Marcus D Hartmann
Architecture and functional dynamics of the pentafunctional AROM complex. Nature chemical biology 16 (9) (2020)
Somsakul Pop Wongpalee, Shiheng Liu, Javier Gallego-Bartolomé, Alexander Leitner, Ruedi Aebersold, Wanlu Liu, Linda Yen, Maria A Nohales, Peggy Hsuanyu Kuo, Ajay A Vashisht, James A Wohlschlegel, Suhua Feng, Steve A Kay, Z Hong Zhou, Steven E Jacobsen
CryoEM structures of Arabidopsis DDR complexes involved in RNA-directed DNA methylation. Nature communications 10 (1) (2019)
Verena Paulitschke, Ossia Eichhoff, Christopher Gerner, Philipp Paulitschke, Andrea Bileck, Thomas Mohr, Phil F Cheng, Alexander Leitner, Emmanuella Guenova, Ieva Saulite, Sandra N Freiberger, Anja Irmisch, Bernhard Knapp, Nina Zila, Theodora-Pagona Chatziisaak, Jürgen Stephan, Joanna Mangana, Rainer Kunstfeld, Hubert Pehamberger, Ruedi Aebersold, Reinhard Dummer, Mitchell Paul Levesque
Proteomic identification of a marker signature for MAPKi resistance in melanoma. The EMBO journal 38 (15) (2019)
Claudio Iacobucci, Christine Piotrowski, Ruedi Aebersold, Bruno C Amaral, Philip Andrews, Katja Bernfur, Christoph H Borchers, Nicolas I Brodie, James E Bruce, Yong Cao, Stéphane Chaignepain, Juan D Chavez, Stéphane Claverol, Juergen Cox, Trisha Davis, Gianluca Degliesposti, Meng-Qiu Dong, Nufar Edinger, Cecilia Emanuelsson, Marina Gay, Michael Götze, Francisco Gomes-Neto, Fabio César Gozzo, Craig Gutierrez, Caroline Haupt, Albert J R Heck, Franz Herzog, Lan Huang, Michael R Hoopmann, Nir Kalisman, Oleg Klykov, Zdeněk Kukačka, Fan Liu, Michael J MacCoss, Karl Mechtler, Ravit Mesika, Robert L Moritz, Nagarjuna Nagaraj, Victor Nesati, Ana G C Neves-Ferreira, Robert Ninnis, Petr Novák, Francis J O'Reilly, Matthias Pelzing, Evgeniy Petrotchenko, Lolita Piersimoni, Manolo Plasencia, Tara Louise Pukala, Kasper Dyrberg Rand, Juri Rappsilber, Dana Reichmann, Carolin Sailer, Chris P Sarnowski, Richard A Scheltema, Carla Schmidt, David C Schriemer, Yi Shi, J Mark Skehel, Moriya Slavin, Frank Sobott, Victor Solis-Mezarino, Heike Stephanowitz, Florian Stengel, Christian E Stieger, Esben Trabjerg, Michael Trnka, Marta Vilaseca, Rosa Viner, Yufei Xiang, Sule Yilmaz, Alex Zelter, Daniel Ziemianowicz, Alexander Leitner, Andrea Sinz
First Community-Wide, Comparative Cross-Linking Mass Spectrometry Study. Analytical chemistry 91 (11) (2019)
David J F Ramrath, Moritz Niemann, Marc Leibundgut, Philipp Bieri, Céline Prange, Elke K Horn, Alexander Leitner, Daniel Boehringer, Andre Schneider, Nenad Ban
Evolutionary shift toward protein-based architecture in trypanosomal mitochondrial ribosomes. Science (New York, N.Y.) 362 (6413) (2018)
Sabina Schütz, Erich Michel, Fred F Damberger, Michaela Oplová, Cohue Peña, Alexander Leitner, Ruedi Aebersold, Frederic H-T Allain, Vikram Govind Panse
Molecular basis for disassembly of an importin:ribosomal protein complex by the escortin Tsr2. Nature communications 9 (1) (2018)
Saikat Chowdhury, Chinatsu Otomo, Alexander Leitner, Kazuto Ohashi, Ruedi Aebersold, Gabriel C Lander, Takanori Otomo
Insights into autophagosome biogenesis from structural and biochemical analyses of the ATG2A-WIPI4 complex. Proceedings of the National Academy of Sciences of the United States of America 115 (42) (2018)
Alexander Leitner
Cross-linking and other structural proteomics techniques: how chemistry is enabling mass spectrometry applications in structural biology. Chemical science 7 (8) (2016)

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Alexander Leitner