Spatial Analysis and Clinical Significance of HLA Class-I and Class-II Subunit Expression in Non-Small Cell Lung Cancer.

Ila J DatarSacha C HaucShruti S Desai Nicole GianinoBrian HenickYuting LiuKostas SyrigosDavid L RimmPaula KavathasSoldano FerroneKurt A Schalper

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2021)

Our results reveal frequent and differential defects in HLA class-I and HLA class-II protein subunit expression in immunotherapy-naïve NSCLCs associated with distinct tumor microenvironment composition and patient survival.

Keyphrases

poor prognosis
binding protein
case report
protein kinase
gene expression
single cell
dna methylation
amino acid