Safety of Opioids in Osteoarthritis: Outcomes of a Systematic Review and Meta-Analysis.

Nicholas FuggleElizabeth M CurtisSarah ShawLaura SpoonerOlivier BruyèreGeorgia NtaniCamille ParsonsPhilip G ConaghanNadia CorpGermain HonvoDaniel UebelhartJanis BairdElaine DennisonJean-Yves Reginster Cyrus Cooper

Published in: Drugs & aging (2019)

Our results confirm that there are considerable safety and tolerability issues surrounding the use of opioids in OA, and support the recommendation of international and national guidelines to use opioids in OA after other analgesic options, and for short time periods.

Keyphrases

chronic pain
pain management
knee osteoarthritis
rheumatoid arthritis
open label
quality improvement
clinical practice
neuropathic pain
randomized controlled trial
type diabetes
spinal cord
spinal cord injury
insulin resistance
weight loss
study protocol