Roles of MYC-targeting long non-coding RNA MINCR in cell cycle regulation and apoptosis in non-small cell lung Cancer.

Shengjie ChenTianyi GuZiwen LuLipeng QiuGuoliang XiaoXiaozhong ZhuFeng LiHui YuGang LiHanqing Liu

Published in: Respiratory research (2019)

MINCR exerted inhibitory effects on the cell cycle arrest and apoptosis of NSCLC cells by activating c-Myc and its downstream effectors, suggesting that this lncRNA could be used as a potential therapeutic target for the treatment of NSCLC.

Keyphrases

cell cycle arrest
long non coding rna
cell cycle
cell death
pi k akt
poor prognosis
small cell lung cancer
cell proliferation
signaling pathway
advanced non small cell lung cancer
transcription factor
oxidative stress
brain metastases
replacement therapy
type iii
endoplasmic reticulum stress