RBM8A, a new target of TEAD4, promotes breast cancer progression by regulating IGF1R and IRS-2.

Fang LiXiaofei WangJing ZhangJinyuan ZhangXintao JingQiuyu JiangJing ZhouLi CaoHang PengDongdong TongChen Huang

Published in: Journal of translational medicine (2024)

Collectively, these findings suggest that TEAD4 novel transcriptional target RBM8A interacts with EIF4A3 to increase IGF1R and IRS-2 expression and activate PI3K/AKT signaling pathway, thereby further promoting the malignant phenotype of BC cells.

Keyphrases

pi k akt
cell cycle arrest
signaling pathway
induced apoptosis
cell proliferation
poor prognosis
binding protein
epithelial mesenchymal transition
gene expression
transcription factor
long non coding rna
cell death