Mystery of neck lump: an uncommon presentation of urachal cancer.
Kamal Kant SahuDeepali PandeyAjay Kumar MishraJames O'SheaYayan ChenBradley McGregorPublished in: BMJ case reports (2019)
We present the case of a 55-year-old male patient who presented with palpable cervical lymphadenopathy. Excisional biopsy showed metastatic adenocarcinoma of unknown origin. Imaging showed a bladder mass following which he underwent transurethral resection of bladder tumour. Histopathological evaluation of mass confirmed a poorly differentiated adenocarcinoma with signet-ring cell features. Immunohistochemistry was suggestive of metastatic urachal cancer. He agreed for enrollment in a clinical trial, however soon after 1st cycle, he developed immune pneumonitis requiring high dose steroids. On follow-up, MRI brain was done for evaluation of headache which showed metastatic intracranial disease. He completed radiotherapy following which he was started on FOLFOX chemo regimen (folinic acid, 5-fluorouracil and oxaliplatin).
Keyphrases
- squamous cell carcinoma
- locally advanced
- papillary thyroid
- small cell lung cancer
- high dose
- clinical trial
- spinal cord injury
- squamous cell
- lymph node metastasis
- case report
- high resolution
- low dose
- early stage
- magnetic resonance imaging
- radiation therapy
- photodynamic therapy
- single cell
- phase ii
- ultrasound guided
- multiple sclerosis
- healthcare
- magnetic resonance
- randomized controlled trial
- diffusion weighted imaging
- mass spectrometry
- open label
- double blind
- metastatic colorectal cancer
- interstitial lung disease
- urinary tract
- computed tomography
- bone marrow
- brain injury
- study protocol
- blood brain barrier
- subarachnoid hemorrhage
- idiopathic pulmonary fibrosis