Mitochondrial GCN5L1 regulates glutaminase acetylation and hepatocellular carcinoma.

Taotao ZhangYunlong CuiYanjin WuJiahui MengLinmeng HanJiaqi ZhangChunyu ZhangChenxi YangLu ChenXue BaiKai ZhangKaiyuan WuMichael N SackLingdi WangLu Zhu

Published in: Clinical and translational medicine (2022)

Our study identified that glutaminase activity, rather than GLS1 or GLS2 expression, is the key factor in HCC development that activates mTORC1 and promotes HCC. In the Kaplan-Meier analysis of liver cancer, we found that HCC patients with high GCN5L1 expression survived longer than those with low GCN5L1 expression. Collectively, GCN5L1 functions as a tumour regulator by modulating glutaminase acetylation and activity in the development of HCC.

Keyphrases

poor prognosis
binding protein
oxidative stress
long non coding rna
signaling pathway
transcription factor