Epigenetic Scanning of KEAP1 CpG Sites Uncovers New Molecular-Driven Patterns in Lung Adeno and Squamous Cell Carcinomas.
Federico Pio FabrizioTommaso MazzaStefano CastellanaAngelo SparaneoLucia Anna MuscarellaPublished in: Antioxidants (Basel, Switzerland) (2020)
These results support the idea that the prognostic role of KEAP1 CpG sites warrants more in-depth investigation and that the impact of their changes in methylation levels may differ among specific NSCLC histologies and molecular backgrounds. Moreover, the observed impact of epigenetic silencing on KEAP1 expression in specific KRAS and EGFR settings may suggest a potential role of KEAP1 methylation as a predictive marker for NSCLC patients for whom anti-EGFR treatments are considered.
Keyphrases
- dna methylation
- small cell lung cancer
- protein protein
- genome wide
- epidermal growth factor receptor
- squamous cell
- end stage renal disease
- gene expression
- advanced non small cell lung cancer
- tyrosine kinase
- ejection fraction
- poor prognosis
- chronic kidney disease
- newly diagnosed
- prognostic factors
- peritoneal dialysis
- small molecule
- brain metastases
- single molecule
- high resolution
- long non coding rna
- high grade
- patient reported outcomes
- mass spectrometry
- electron microscopy
- human health