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A general score-independent test for order-restricted inference.

Henric WinellJohan Lindbäck
Published in: Statistics in medicine (2018)
In the analysis of ordered categorical data, the categories are often assigned a set of subjectively chosen order-restricted scores. To overcome the arbitrariness involved in the assignment of the scores, several score-independent tests have been proposed. However, these methods are limited to 2 × K contingency tables, where K is the number of ordered categories. We present an efficiency robust score-independent test that is applicable to more general situations. The test is embedded into a flexible framework for conditional inference and provides a natural generalization of many familiar tests involving ordered categorical data, such as the generalized Cochran-Mantel-Haenszel test for singly or doubly ordered contingency tables, the Page test for randomized block designs and the Tarone-Ware trend test for survival data. The proposed method is illustrated by several numerical examples.
Keyphrases
  • electronic health record
  • big data
  • randomized controlled trial
  • single cell
  • open label
  • double blind
  • data analysis
  • placebo controlled
  • phase iii
  • study protocol