Clinical predictors of donor antibody titre and correlation with recipient antibody response in a COVID-19 convalescent plasma clinical trial.
Maria Lucia L MadariagaJ J GuthmillerS SchrantzM O JansenC ChristensenM KumarM ProchaskaG WoolA Durkin-CelauroW H OhL TrockmanJ VigneswaranR KeskeyD G ShawH DuganN-Y ZhengM CobbH UtsetJ WangO StovicekC BethelS MatushekM GiurcanuK G BeavisD di SabatoD MeltzerM K FergusonJ P KressK ShanmugarajahJ B MatthewsJ F FungP C WilsonJ C AlverdyJ S DoningtonPublished in: Journal of internal medicine (2020)
Advanced age, fever, absence of myalgia, fatigue, blood type and hospitalization were associated with higher convalescent antibody titre to COVID-19. Despite variability in donor titre, 80% of convalescent plasma recipients showed significant increase in antibody levels post-transfusion. A more complete understanding of the dose-response effect of plasma transfusion amongst COVID-19-infected patients is needed.