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Proteome-wide association study and functional validation identify novel protein markers for pancreatic ductal adenocarcinoma.

Jingjing ZhuKe WuShuai LiuAlexandra MascaHua ZhongTai YangDalia H GhoneimPraveen SurendranTanxin LiuQizhi YaoTao LiuSarah FahleAdam ButterworthMd Ashad AlamJaydutt V VadgamaYouping DengHong-Wen DengChong WuYong WuLang Wu
Published in: GigaScience (2024)
PDAC is a notoriously difficult-to-treat malignancy, and our limited understanding of causal protein markers hampers progress in developing effective early detection strategies and treatments. Our study identifies novel causal proteins using genetic instruments and subsequently functionally validates selected novel proteins. This dual approach enhances our understanding of PDAC etiology and potentially opens new avenues for therapeutic interventions.
Keyphrases
  • genome wide
  • binding protein
  • dna methylation