Long non-coding RNA AFAP1-AS1 promoting epithelial-mesenchymal transition of endometriosis is correlated with transcription factor ZEB1.

Dianchao LinQiansheng HuangRongfeng WuSongjuan DaiZhixiong HuangLulu RenSijing HuangQiong-Hua Chen

Published in: American journal of reproductive immunology (New York, N.Y. : 1989) (2018)

Higher expression of AFAP1-AS1 positively correlated with greater EMT in ectopic endometrium of patients with endometriosis. Knockdown of AFAP1-AS1 inhibited E2-induced activity of promoter site pGL3-P886 of transcription factor ZTB1, suggesting that AFAP1-AS1 knockdown inhibited growth of endometrial epithelial cells and that pathogenesis may be correlated with EMT.

Keyphrases

epithelial mesenchymal transition
long non coding rna
transcription factor
poor prognosis
transforming growth factor
signaling pathway
dna binding
diabetic rats
gene expression
genome wide identification
oxidative stress
stress induced