Unraveling Vulnerabilities in Endocrine Therapy-Resistant HER2+/ER + Breast Cancer.

Shaymaa Bahnassy Hillary S AndrewsLu JinStanley TamDua MobinManasi Balachandran Mircea PodarMatthew D McCoyRobert A BeckmanRebecca B Riggins

Published in: Endocrinology (2023)

The BT474 and MM361 AI-resistant models capture distinct phenotypes of HER2+/ER + BCa and identify altered lipid metabolism and ferroptosis remodeling as vulnerabilities of this type of ETR BCa.

Keyphrases

estrogen receptor
endoplasmic reticulum
breast cancer cells
cell death
artificial intelligence
stem cells
fatty acid
machine learning
young adults
cell therapy
breast cancer risk