S100A14: A novel negative regulator of cancer stemness and immune evasion by inhibiting STAT3-mediated programmed death-ligand 1 expression in colorectal cancer.

Hye-Young MinJaebeom ChoJeong Yeon SimHye-Jin BooJi-Sun LeeSeon-Boon LeeYoung-Jin LeeSung Joo KimKyu-Pyo KimIn-Ja ParkSeung-Mo HongXue-Li ZhangZhi-Gang ZhangRang-Woon ParkHo-Young Lee

Published in: Clinical and translational medicine (2022)

Our results suggest that SA14-based therapy is an effective strategy to prevent tumour progression and that SA14 is a predictive biomarker for anti-PD-L1 immunotherapy and chemotherapy in combination.

Keyphrases

papillary thyroid
poor prognosis
stem cells
epithelial mesenchymal transition
squamous cell
signaling pathway
cell proliferation
transcription factor
locally advanced
lymph node metastasis
long non coding rna
radiation therapy
cancer stem cells
chemotherapy induced