Systematic druggable genome-wide Mendelian randomization identifies therapeutic targets for sarcopenia.

Kang-Fu YinTing ChenXiao-Jing GuWei-Ming SuZheng JiangSi-Jia LuBei CaoLi-Yi ChiXia GaoYong-Ping Chen

Published in: Journal of cachexia, sarcopenia and muscle (2024)

Our research indicated MAP 3K3, MFGE8, COL15A1, HP, and HLA-DRA may serve as promising targets for sarcopenia, while the effectiveness of zinc supplementation and collagenase clostridium histolyticum for sarcopenia requires further validation.

Keyphrases

genome wide
skeletal muscle
community dwelling
dna methylation
randomized controlled trial
systematic review
copy number
gene expression
high density