New Insights on the Therapeutic Potential of Runt-Related Transcription Factor 2 for Osteoarthritis: Evidence from Mendelian Randomization.

Jiale XieXin XuMingyi YangHui YuJinrong HaoDinglong YangPeng Xu

Published in: Rheumatology and therapy (2024)

Our analyses indicate a positive correlation between Runx2 expression and OA risk across all three phenotypes, suggesting the potential of Runx2 inhibitors in the treatment of OA and providing evidence from a genetic perspective.

Keyphrases

transcription factor
knee osteoarthritis
dna binding
poor prognosis
rheumatoid arthritis
genome wide identification
genome wide
binding protein
copy number
combination therapy
gene expression
climate change
dna methylation
long non coding rna
replacement therapy