Adult stem cell-derived complete lung organoid models emulate lung disease in COVID-19.
Courtney TindleMacKenzie FullerAyden FonsecaSahar TaheriStella-Rita IbeawuchiNathan BeutlerGajanan Dattatray KatkarAmanraj ClaireVanessa CastilloMoises HernandezHana RussoJason DuranLaura E Crotty AlexanderAnn TippsGrace LinPatricia A ThistlethwaiteRanajoy ChattopadhyayThomas F RogersDebashis SahooPradipta GhoshSoumita DasPublished in: eLife (2021)
This work was supported by the National Institutes for Health (NIH) grants 1R01DK107585-01A1, 3R01DK107585-05S1 (to SD); R01-AI141630, CA100768 and CA160911 (to PG) and R01-AI 155696 (to PG, DS and SD); R00-CA151673 and R01-GM138385 (to DS), R01- HL32225 (to PT), UCOP-R00RG2642 (to SD and PG), UCOP-R01RG3780 (to P.G. and D.S) and a pilot award from the Sanford Stem Cell Clinical Center at UC San Diego Health (P.G, S.D, D.S). GDK was supported through The American Association of Immunologists Intersect Fellowship Program for Computational Scientists and Immunologists. L.C.A's salary was supported in part by the VA San Diego Healthcare System. This manuscript includes data generated at the UC San Diego Institute of Genomic Medicine (IGC) using an Illumina NovaSeq 6000 that was purchased with funding from a National Institutes of Health SIG grant (#S10 OD026929).
Keyphrases
- stem cells
- public health
- healthcare
- quality improvement
- mental health
- health information
- artificial intelligence
- sars cov
- coronavirus disease
- randomized controlled trial
- clinical trial
- gene expression
- copy number
- climate change
- electronic health record
- dna methylation
- mesenchymal stem cells
- cell therapy
- big data
- deep learning