COPD basal cells are primed towards secretory to multiciliated cell imbalance driving increased resilience to environmental stressors.

Mircea-Gabriel StoleriuMeshal AnsariMaximilian StrunzAndrea SchambergerMotaharehsadat HeydarianYaobo DingCarola VossJuliane Josephine SchneiderMichael GerckensGerald BurgstallerAlejandra CastelblancoTeresa KaukeJan FertmannChristian SchneiderJuergen BehrMichael LindnerElvira Stacher-PriehseMartin IrmlerJohannes BeckersOliver EickelbergBenjamin SchubertStefanie M HauckOtmar SchmidRudolf A HatzTobias StoegerHerbert B SchillerAnne Hilgendorff

Published in: Thorax (2024)

We identified COPD stage-specific gene alterations in basal cells that affect the cellular composition of the bronchial elevator and may control disease-specific epithelial resilience mechanisms in response to environmental nanoparticles. The identified phenomena likely inform treatment and prevention strategies.

Keyphrases

induced apoptosis
chronic obstructive pulmonary disease
cell cycle arrest
climate change
lung function
endoplasmic reticulum stress
social support
genome wide
stem cells
human health
cell death
oxidative stress
gene expression
copy number
depressive symptoms
risk assessment
cell proliferation
air pollution