The Efficacy, Effectiveness and Safety of 5% Transdermal Lidocaine Patch for Chronic Low Back Pain: A Narrative Review.

Local anesthetics, such as the 5% transdermal lidocaine patch (5LP), have been frequently used in the treatment of musculoskeletal pain, especially chronic low back pain (CLBP). This review compiles the literature available on the efficacy, effectiveness, and safety of 5LP when used for the management of CLBP. A systematic search method revealed seven articles that fit the inclusion criteria. For each study, efficacy, effectiveness, and adverse events data were extracted. We found no randomized controlled trials with substantial evidence to support the use of 5LP in CLBP, despite the presence of nonrandomized noncontrolled trials suggesting its effectiveness for relief of pain. Future randomized controlled trials with clinically useful outcomes are needed to assess the efficacy, effectiveness, and safety of 5LP for CLBP more appropriately.