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Rh(III) and Ru(II) complexes with phosphanyl-alkylamines: inhibition of DNA synthesis induced by anticancer Rh complex.

Alena MrkvicovaEva PeterovaIvan NemecRadka KřikavováDarina MuthnáRadim HavelekPetra KazimírováMartina ŘezáčováPavel Štarha
Published in: Future medicinal chemistry (2023)
Aim: This investigation was designed to synthesize half-sandwich Rh(III) and Ru(II) complexes and study their antiproliferative activity in human cancer cell lines. Materials & methods: Nine compounds were prepared and tested by various assays for their anticancer activity and mechanism of action. Results: Hit Rh(III) complex 6 showed low-micromolar potency in cisplatin-sensitive (A2780) and -resistant (A2780cis) ovarian carcinoma cell lines, promising selectivity toward these cancer cells over normal lung fibroblasts and an unprecedented mechanism of action in the treated cells. DNA synthesis was decreased and CDKN1A expression was upregulated, but p21 expression was not induced. Conclusion: Rh complex 6 showed high antiproliferative activity, which is induced through a p21-independent mechanism of action.
Keyphrases
  • poor prognosis
  • high glucose
  • endothelial cells
  • diabetic rats
  • circulating tumor
  • induced apoptosis
  • cell free
  • single molecule
  • drug induced
  • oxidative stress
  • nucleic acid
  • signaling pathway
  • extracellular matrix