UCP1 expression in human brown adipose tissue is inversely associated with cardiometabolic risk factors.
T'ng Choong KwokLynne E RamageAlexandra KelmanKarla J SuchackiCalum D GrayLuke D BoyleRobert K SempleTom MacGillivrayGillian MacNaughtDilip PatelEdwin J R van BeekRobert K SempleSonia J WakelinRoland H StimsonPublished in: European journal of endocrinology (2024)
18F-FDG uptake by BAT and UCP1 expression are preserved in young obese adults. Older subjects retain precursor cells with the capacity to form new thermogenic adipocytes. These data highlight the therapeutic potential of BAT mass expansion and activation in obesity.
Keyphrases
- adipose tissue
- poor prognosis
- insulin resistance
- risk factors
- metabolic syndrome
- weight loss
- type diabetes
- induced apoptosis
- endothelial cells
- high fat diet
- middle aged
- binding protein
- cell cycle arrest
- electronic health record
- pet ct
- weight gain
- signaling pathway
- long non coding rna
- cell death
- obese patients
- positron emission tomography
- oxidative stress
- computed tomography
- community dwelling