Plasma circulating tumor DNA profiling in patients with chemo-refractory germ cell tumors.
Shotaro SakkaSyuya KandoriKoji KawaiTakahiro KojimaSatoshi NittaIchiro ChiharaYoshiyuki NagumoTakashi KawaharaBryan J MathisMegumi IshiharaNobuo ShinoharaTakeshi KishidaOsamu UkimuraKazuo NishimuraYasuyuki KobayashiHiroyuki NishiyamaPublished in: International journal of urology : official journal of the Japanese Urological Association (2023)
Analysis of plasma circulating tumor DNA could detect genetic alterations in patients with chemo-refractory GCT. Moreover, detectable circulating tumor DNA in plasma was associated with poor prognosis in those patients. These results suggest that liquid biopsy using analysis of plasma circulating tumor DNA may be clinically useful for germ cell tumor patients.
Keyphrases
- circulating tumor
- cell free
- circulating tumor cells
- poor prognosis
- germ cell
- end stage renal disease
- ejection fraction
- newly diagnosed
- prognostic factors
- long non coding rna
- squamous cell carcinoma
- patient reported outcomes
- cancer therapy
- ionic liquid
- combination therapy
- locally advanced
- single molecule
- fine needle aspiration