Apelin is expressed throughout the human kidney, is elevated in chronic kidney disease & associates independently with decline in kidney function.
Duuamene NyimanuFiona A ChapmanPeter J GallacherRhoda E KucThomas L WilliamsDavid E NewbyJanet J MaguireAnthony P DavenportNeeraj DhaunPublished in: British journal of clinical pharmacology (2022)
We show for the first time that the apelin system is expressed in healthy human kidney. Plasma apelin is elevated in CKD and may be a potential biomarker of risk of decline in kidney function. Clinical studies exploring the therapeutic potential of apelin agonism in CKD are warranted.