SARS-CoV-2 Interference of Influenza Virus Replication in Syrian Hamsters.

Peter J HalfmannNoriko NakajimaYuko SatoKenta TakahashiMolly AccolaShiho ChiboShufang FanGabriele NeumannWilliam RehrauerTadaki SuzukiYoshihiro Kawaoka

Published in: The Journal of infectious diseases (2021)

The effects of simultaneous or serial infections with SARS-CoV-2 and influenza virus are unknown. Here, we report that, in a hamster model, SARS-CoV-2 infection at the same time as or prior to H3N2 influenza virus infection resulted in significantly reduced influenza virus titers in the lungs and nasal turbinates of infected animals. This interference of influenza virus replication may correlate with SARS-CoV-2-induced expression of the antiviral gene MX1.

Keyphrases

sars cov
respiratory syndrome coronavirus
poor prognosis
genome wide
gene expression
diabetic rats
high glucose
dna methylation
transcription factor