Focus Issue: Cancer-Beyond tumor genetics to protein landscapes.
Leslie K FerrarelliNancy R GoughPublished in: Science signaling (2017)
The proteins that regulate cell proliferation, metastatic potential, survival in circulation, and immune evasion represent most of the targets for therapeutic intervention in cancer. Furthermore, genomic profiling of just the cancer cells leaves critical information about the tumor microenvironment in the dark. The articles highlighted in this Focus Issue describe efforts to translate genomic data into knowledge of aberrant signaling that can be therapeutically targeted and strategies to explore not only the changes that occur in the protein landscape of the tumors but also in the protein profiles of the tumor microenvironment.
Keyphrases
- papillary thyroid
- cell proliferation
- protein protein
- randomized controlled trial
- healthcare
- squamous cell
- squamous cell carcinoma
- amino acid
- binding protein
- single cell
- copy number
- electronic health record
- small molecule
- gene expression
- big data
- risk assessment
- drug delivery
- quality improvement
- lymph node metastasis
- artificial intelligence
- human health