Vitamin D facilitates trophoblast invasion through induction of epithelial-mesenchymal transition.

Ryang Hee KimByung Jun RyuKi Mo LeeJae Won HanSung Ki Lee

Published in: American journal of reproductive immunology (New York, N.Y. : 1989) (2017)

Calcitriol facilitated EMT induction and expression of MMPs via ERK signaling pathway, which promoted the invasive capability of EVTs. Further studies are warranted to elucidate the potential application of vitamin D in the prevention of pregnancy complications.

Keyphrases

epithelial mesenchymal transition
signaling pathway
pi k akt
transforming growth factor
poor prognosis
induced apoptosis
preterm birth
risk factors
cell migration
cell proliferation
binding protein
case control
long non coding rna