γ-Oryzanol Ameliorates Depressive Behavior in Ovariectomized Mice by Regulating Hippocampal Nitric Oxide Synthase: A Potential Therapy for Menopausal Depression.
Minji KimMinseok YoonSuengmok ChoChangho LeeMin Young UmPublished in: Molecular nutrition & food research (2023)
The results indicate that ORY attenuates depressive behavior in OVX mice by upregulating ERβ-mediated hippocampal nNOS expression and activating the ERK-CREB-BDNF signaling networks. The findings suggest that ORY is a potential therapeutic agent for attenuating menopausal depression.
Keyphrases
- nitric oxide synthase
- nitric oxide
- signaling pathway
- stress induced
- depressive symptoms
- high fat diet induced
- bipolar disorder
- poor prognosis
- sleep quality
- cerebral ischemia
- cell proliferation
- mouse model
- pi k akt
- wild type
- climate change
- type diabetes
- estrogen receptor
- long non coding rna
- breast cancer cells
- brain injury
- physical activity