Enhanced hepatic respiratory capacity and altered lipid metabolism support metabolic homeostasis during short-term hypoxic stress.
Katie A O'BrienBen D McNallyAlice P SowtonAntonio MurgiaJames ArmitageLuke W ThomasFynn N KrauseLucas A MaddalenaIan FrancisStefan KavanaghDominic P WilliamsMargaret AshcroftJulian L GriffinJonathan J LyonAndrew J MurrayPublished in: BMC biology (2021)
The liver maintains metabolic homeostasis in response to shorter term hypoxic exposure through transient enhancement of respiratory chain capacity and alterations to lipid metabolism. These findings may have implications in understanding and treating hepatic pathologies associated with hypoxia.