Modulation of Target Antigen Density Improves CAR T-cell Functionality and Persistence.

Sneha RamakrishnaSteven L HighfillZachary WalshSang M NguyenHaiyan LeiJack F Shern Haiying QinIra L KraftMaryalice Stetler-StevensonConstance M YuanJennifer D HwangYang FengZhongyu ZhuDimiter DimitrovNirali N ShahTerry J Fry

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2019)

We demonstrate that target antigen modulation is a promising strategy to improve CD22 CAR efficacy and remission durability in patients with leukemia and lymphoma.See related commentary by Guedan and Delgado, p. 5188.

Keyphrases

single cell
acute myeloid leukemia
diffuse large b cell lymphoma
cell therapy
disease activity
stem cells
rheumatoid arthritis
ulcerative colitis
nk cells