Human hypofunctional NCF1 variants promote pulmonary fibrosis in the bleomycin-induced mouse model and patients with systemic sclerosis via expansion of SPP1 + monocytes-derived macrophages.
Xinran YuanXiaodong QinKenji TakemotoJian ZhaoMatthew SandersonXue XuYu ZhangKristi L HelkeBethany Jacobs WolfJoel M GuthridgeJudith A JamesXiaodong ZhouShervin AssassiCarol A Feghali-BostwickDandan WangLingyun SunBetty P TsaoPublished in: Annals of the rheumatic diseases (2024)
MoMs in a CCL2-dependent manner, contributing to the severity of lung fibrosis in both BLM-treated mice and patients with SSc.
Keyphrases
- pulmonary fibrosis
- systemic sclerosis
- interstitial lung disease
- mouse model
- endothelial cells
- high glucose
- liver fibrosis
- drug induced
- liver injury
- diabetic rats
- induced pluripotent stem cells
- high fat diet induced
- copy number
- pluripotent stem cells
- peripheral blood
- type diabetes
- immune response
- gene expression
- rheumatoid arthritis
- adipose tissue
- idiopathic pulmonary fibrosis
- insulin resistance