The gathering of information through the use of interrogation techniques in the context of human intelligence (HUMINT) has a long and elusive history within applied settings of law enforcement and the military and civilian intelligence/counterterrorism community. However, psychological research has yet to catch up to systematically address pressing matters regarding the validity and effectiveness of common interrogation methods and a conceptual framework for relevant psychological factors. A promising, comprehensive contribution is the Taxonomy of Interrogation Methods (ToIM), which aims to integrate multiple approaches within the field of interrogation. In this paper, we utilized the ToIM model as a foundation for a meta-analytic review on the validity and effectiveness of interrogation techniques. We systematically integrated the existing evidence from 60 studies in order to determine which techniques from six domains of the ToIM produce valuable information. The results indicate that Rapport and Relationship Building , Presentation of Evidence and Cognitive Facilitation (an additional domain beyond the ToIM) are valid approaches to optimize both the amount of information gathered as well as its accuracy. The evidence is insufficient to conclude the effectiveness of techniques from the other four domains. Overall, the results are in line with the general notion in the field that a positive relationship with a suspect/source is the key to gather valuable information.