The Oncogenic Lipid Sphingosine-1-Phosphate Impedes the Phagocytosis of Tumor Cells by M1 Macrophages in Diffuse Large B Cell Lymphoma.
Tracey A PerryNavta MasandKaterina VrzalikovaMatthew Richard PughWenbin WeiRobert HollowsKateřina BouchalováMahdi NohtaniEanna FennellJan BouchalPamela KearnsPaul G MurrayPublished in: Cancers (2024)
Our data show that S1P signaling can modulate macrophage recruitment and tumor cell killing by anti-CD20 monoclonal antibodies in DLBCL. The administration of S1PR1 inhibitors could enhance the phagocytosis of tumor cells and improve outcomes for patients.
Keyphrases
- diffuse large b cell lymphoma
- epstein barr virus
- end stage renal disease
- ejection fraction
- newly diagnosed
- chronic kidney disease
- single cell
- prognostic factors
- adipose tissue
- peritoneal dialysis
- metabolic syndrome
- skeletal muscle
- transcription factor
- fatty acid
- patient reported outcomes
- machine learning
- mesenchymal stem cells
- bone marrow
- insulin resistance
- deep learning
- weight loss
- patient reported