Protective effects of GHRH antagonists against hydrogen peroxide-induced lung endothelial barrier disruption.

Mohammad S AkhterKhadeja-Tul KubraNektarios Barabutis

Published in: Endocrine (2022)

GHRHAnt represent a promising therapeutic intervention towards diseases related to lung endothelial hyperpermeability, such as acute respiratory distress syndrome - related or not to COVID-19 - and sepsis. Targeted medicine for those potentially lethal disorders does not exist.

Keyphrases

hydrogen peroxide
acute respiratory distress syndrome
extracorporeal membrane oxygenation
endothelial cells
mechanical ventilation
nitric oxide
sars cov
coronavirus disease
randomized controlled trial
high glucose
intensive care unit
acute kidney injury
cancer therapy