Rare Variant in Metallothionein 1E Increases the Risk of Type 2 Diabetes in a Chinese Population.

Xiantong ZouMengdie HuXiuting HuangLingli ZhouMeng LiJing ChenLiping MaXueying GaoYingying LuoXiaoling CaiYufeng LiXianghai ZhouNa LiYuanping ShiXueyao HanXiantong Zou

Published in: Diabetes care (2023)

Our results suggest that MT1E could be a promising target for drug development, because forced expression of MT1E p.C36C stabilized glucose metabolism and reduced body weight, whereas MT1E p.C36Y expression had the opposite effect. These findings highlight the importance of considering the impact of rare variants in the development of new T2D treatments.

Keyphrases

body weight
poor prognosis
binding protein
copy number
gene expression
dna methylation