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Celastrus paniculatus oil ameliorates NF-KB mediated neuroinflammation and synaptic plasticity in the scopolamine-induced cognitive impairment rat model.

Khushboo Govind FalduSnehal Sanjay PatelJigna Samir Shah
Published in: Metabolic brain disease (2023)
Our data is suggestive that CP oil treatment improves behavioural test outcomes, increases biogenic amine concentration, and decreases acetylcholinesterase activity, and neuroinflammatory biomarkers. It also restores synaptic plasticity. It thus improves cognitive functions against scopolamine-induced amnesia in rats by improving cholinergic function.
Keyphrases
  • cognitive impairment
  • high glucose
  • diabetic rats
  • lps induced
  • drug induced
  • signaling pathway
  • fatty acid
  • type diabetes
  • immune response
  • metabolic syndrome
  • lipopolysaccharide induced
  • big data
  • stress induced