Single-cell sequencing reveals antitumor characteristics of intratumoral immune cells in old mice.

Cangang ZhangLei LeiXiaofeng YangKaili MaHuiqiang ZhengYanhong SuAnjun JiaoXin WangHaiyan LiuYujing ZouLin ShiXiaobo ZhouChenming SunYuzhu HouZhengtao XiaoLianjun ZhangBaojun Zhang

Published in: Journal for immunotherapy of cancer (2022)

Our data revealed that a significantly higher proportion of effector immune cells in old mice defends against tumor progression, providing insights into understanding the altered kinetics of cancer development and the differential response to immunotherapeutic modulation in elderly patients.

Keyphrases

single cell
rna seq
high fat diet induced
papillary thyroid
high throughput
poor prognosis
dendritic cells
regulatory t cells
adipose tissue
immune response
insulin resistance
squamous cell carcinoma
lymph node metastasis
deep learning
childhood cancer
type iii
aqueous solution