Intratumoral G100, a TLR4 Agonist, Induces Antitumor Immune Responses and Tumor Regression in Patients with Merkel Cell Carcinoma.
Shailender BhatiaNatalie J MillerHailing LuNatalie V LonginoDafina IbraniMichi M ShinoharaDavid R ByrdUpendra ParvathaneniRima KulikauskasJan Ter MeulenFrank J HsuDavid M KoellePaul T NghiemPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2018)
In this first-in-human study, IT G100 induced antitumor immune responses, demonstrated acceptable safety, and showed encouraging clinical activity.See related commentary by Marquez-Rodas et al., p. 1127.