Clinically Meaningful Magnetic Resonance Endpoints Sensitive to Preataxic Spinocerebellar Ataxia Types 1 and 3.
Jayashree ChandrasekaranEmilien PetitYoung Woo ParkSophie Tezenas du MontcelJames M JoersDinesh K DeelchandMichal PovažanGuita BananRomain ValabreguePhilipp EhsesJennifer FaberPierrick CoupéChiadi U OnyikePeter B BarkerJeremy D SchmahmannEva-Maria RataiSub H SubramonyThomas H MareciKhalaf O BusharaHenry PaulsonAlexandra DurrThomas KlockgetherTetsuo AshizawaChristophe LengletGülin Öznull nullPublished in: Annals of neurology (2022)
Changes in cerebellar afferent and efferent pathways underlie the earliest symptoms of both SCAs. MR metrics collected with a harmonized advanced protocol in the multisite trial setting allow detection of disease effects in individuals before ataxia onset with potential clinical trial utility for subject stratification. ANN NEUROL 2022.
Keyphrases
- magnetic resonance
- clinical trial
- phase ii
- study protocol
- phase iii
- early onset
- contrast enhanced
- randomized controlled trial
- open label
- label free
- loop mediated isothermal amplification
- real time pcr
- human health
- magnetic resonance imaging
- sleep quality
- neural network
- risk assessment
- physical activity
- depressive symptoms
- computed tomography
- climate change