The Transcription Factor PLZF Is Necessary for the Development and Function of Mouse Basophils.
Sai ZhangJoshua A ViethAgata KrzyzanowskaEverett K HenryLisa K DenzinMark C SiracusaDerek B Sant'AngeloPublished in: Journal of immunology (Baltimore, Md. : 1950) (2019)
Basophils are innate immune cells associated with type 2 immunity, allergic reactions, and host defense against parasite infections. In this study, we show that the transcription factor PLZF, which is known for its essential role in the function and development of several innate lymphocyte subsets, is also important for the myeloid-derived basophil lineage. PLZF-deficient mice had decreased numbers of basophil progenitors in the bone marrow and mature basophils in multiple peripheral tissues. Functionally, PLZF-deficient basophils were less responsive to IgE activation and produced reduced amounts of IL-4. The altered function of basophils resulted in a blunted Th2 T cell response to a protein allergen. Additionally, PLZF-deficient basophils had reduced expression of the IL-18 receptor, which impacted migration to lungs. PLZF, therefore, is a major player in controlling type 2 immune responses mediated not only by innate lymphocytes but also by myeloid-derived cells.
Keyphrases
- immune response
- bone marrow
- transcription factor
- dendritic cells
- peripheral blood
- induced apoptosis
- toll like receptor
- acute myeloid leukemia
- poor prognosis
- gene expression
- mesenchymal stem cells
- binding protein
- cell cycle arrest
- cell death
- oxidative stress
- endoplasmic reticulum stress
- allergic rhinitis
- drug delivery
- protein protein
- inflammatory response
- life cycle