Transvaginal Ultrasound Accuracy in the Hydrosalpinx Diagnosis: A Systematic Review and Meta-Analysis.
Aina Delgado-MorellMar Nieto-TousCristina Andrada-RipollésMaria Angela PascualSilvia AjossaStefano GuerrieroJuan Luis AlcazarPublished in: Diagnostics (Basel, Switzerland) (2023)
Hydrosalpinx is a condition with a crucial prognostic role in reproduction, and its diagnosis by a non-invasive technique such as ultrasound is key in achieving an adequate reproductive assessment while avoiding unnecessary laparoscopies. The aim of the present systematic review and meta-analysis is to synthetize and report the current evidence on transvaginal sonography (TVS) accuracy to diagnose hydrosalpinx. Articles on the topic published between January 1990 and December 2022 were searched in five electronic databases. Data from the six selected studies, comprising 4144 adnexal masses in 3974 women, 118 of which were hydrosalpinxes, were analyzed as follows: overall, TVS had a pooled estimated sensitivity for hydrosalpinx of 84% (95% confidence interval (CI) = 76-89%), specificity of 99% (95% CI = 98-100%), positive likelihood ratio of 80.7 (95% CI = 33.7-193.0), and negative likelihood ratio of 0.16 (95% CI = 0.11-0.25) and DOR of 496 (95% CI = 178-1381). The mean prevalence of hydrosalpinx was 4%. The quality of the studies and their risk of bias were assessed using QUADAS-2, evidencing an overall acceptable quality of the selected articles. We concluded that TVS has a good specificity and sensitivity for diagnosing hydrosalpinx.
Keyphrases
- magnetic resonance imaging
- contrast enhanced
- risk factors
- big data
- contrast enhanced ultrasound
- electronic health record
- type diabetes
- case control
- polycystic ovary syndrome
- machine learning
- magnetic resonance
- computed tomography
- clinical trial
- randomized controlled trial
- deep learning
- meta analyses
- phase iii
- cervical cancer screening