Emerging biological functions of Twist1 in cell differentiation.
Mengjie TuBingqian GeJiali LiYanbing PanBinbin ZhaoJiayang HanJialin WuKaifeng ZhangGuangchao LiuMengwen HouMan YueXu HanTiantian SunYang AnPublished in: Developmental dynamics : an official publication of the American Association of Anatomists (2024)
Twist1 is required for embryonic development and expresses after birth in mesenchymal stem cells derived from mesoderm, where it governs mesenchymal cell development. As a well-known regulator of epithelial-mesenchymal transition or embryonic organogenesis, Twist1 is important in a variety of developmental systems, including mesoderm formation, neurogenesis, myogenesis, cranial neural crest cell migration, and differentiation. In this review, we first highlight the physiological significance of Twist1 in cell differentiation, including osteogenic, chondrogenic, and myogenic differentiation, and then detail its probable molecular processes and signaling pathways. On this premise, we summarize the significance of Twist1 in distinct developmental disorders and diseases to provide a reference for studies on cell differentiation/development-related diseases.
Keyphrases
- epithelial mesenchymal transition
- mesenchymal stem cells
- signaling pathway
- cell migration
- transforming growth factor
- bone marrow
- umbilical cord
- cell therapy
- stem cells
- skeletal muscle
- single cell
- transcription factor
- pi k akt
- induced apoptosis
- cell proliferation
- brain injury
- subarachnoid hemorrhage
- preterm birth
- cerebral ischemia
- blood brain barrier
- pluripotent stem cells
- drug induced
- pregnancy outcomes