Confocal laser endomicroscopy as predictive biomarker of clinical and endoscopic efficacy of vedolizumab in ulcerative colitis: The DETECT study.

Lucille QuénéhervéCaroline Trang-PoissonAurélie FantouMathurin FlamantTony DurandGuillaume BouguenJérémy BregeonThibauld OullierMorgane AmilMarie DewitteStéphanie BardotStéphanie BlandinCécile BraudeauMarie-Anne VibetRégis JosienMichel NeunlistArnaud Bourreille

Published in: PloS one (2024)

This pilot study demonstrate that dual-band CLE is feasible to detect α4β7- and TNF-expressing cells. Positive α4β7 staining seems to be associated with clinical and endoscopic remission in UC patients treated by anti-α4β7-integrin, subject to validation by larger-scale studies. Clinical-trial.gov: NCT02878083.

Keyphrases

ulcerative colitis
clinical trial
ultrasound guided
induced apoptosis
rheumatoid arthritis
oxidative stress
cell cycle arrest
randomized controlled trial
open label
mass spectrometry
signaling pathway
cell proliferation
phase ii
high resolution
endoscopic submucosal dissection