Strepantibins A-C: Hexokinase II Inhibitors from a Mud Dauber Wasp Associated Streptomyces sp.
Ya-Jie SongHong-Bo ZhengAi-Hong PengJia-Hui MaDan-Dan LuXia LiHang-Yu ZhangWei-Dong XiePublished in: Journal of natural products (2019)
Two new p-terphenyls, strepantibins A and B (1 and 2), along with the first representative of a naturally occurring bisphenyltropone, strepantibin C (3), were characterized from a Streptomyces sp. associated with the larvae of the mud dauber wasp Sceliphron madraspatanum. Their structures were determined by high-resolution electrospray ionization mass spectrometry, NMR, and X-ray crystallography data interpretation. Strepantibins A-C inhibited hexokinase II (HK2) activity and displayed antiproliferative activity against hepatoma carcinoma cells HepG-2, SMMC-7721 and plc-prf-5. In SMMC-7721 cells treated with strepantibin A, the morphological characteristics of apoptosis were observed.
Keyphrases
- high resolution
- mass spectrometry
- cell cycle arrest
- induced apoptosis
- endoplasmic reticulum stress
- cell death
- oxidative stress
- liquid chromatography
- magnetic resonance
- tandem mass spectrometry
- cross sectional
- electronic health record
- magnetic resonance imaging
- big data
- pi k akt
- signaling pathway
- capillary electrophoresis
- machine learning
- data analysis
- aedes aegypti
- dual energy