Omentin: A Key Player in Glucose Homeostasis, Atheroprotection, and Anti-Inflammatory Potential for Cardiovascular Health in Obesity and Diabetes.
Cristina M SenaPublished in: Biomedicines (2024)
Omentin is an adipokine mainly produced by visceral fat tissue. It has two isoforms, omentin-1 and omentin-2. Omentin-1 is predominantly secreted by visceral adipose tissue, derived specifically from the stromal vascular fraction cells of white adipose tissue (WAT). Levels of omentin-1 are also expressed in other WAT depots, such as epicardial adipose tissue. Omentin-1 exerts several beneficial effects in glucose homeostasis in obesity and diabetes. In addition, research has suggested that omentin-1 may have atheroprotective (protective against the development of atherosclerosis) and anti-inflammatory effects, potentially contributing to cardiovascular health. This review highlights the potential therapeutic targets of omentin-1 in metabolic disorders.
Keyphrases
- adipose tissue
- insulin resistance
- type diabetes
- cardiovascular disease
- metabolic syndrome
- high fat diet
- weight loss
- anti inflammatory
- high fat diet induced
- induced apoptosis
- blood glucose
- glycemic control
- oxidative stress
- blood pressure
- body mass index
- risk assessment
- weight gain
- fatty acid
- cell death
- african american
- signaling pathway