Partly interval-censored data often occur in cancer clinical trials and have been analyzed as right-censored data. Patients' geographic information sometimes is also available and can be useful in testing treatment effects and predicting survivorship. We propose a Bayesian semiparametric method for analyzing partly interval-censored data with areal spatial information under the proportional hazards model. A simulation study is conducted to compare the performance of the proposed method with the main method currently available in the literature and the traditional Cox proportional hazards model for right-censored data. The method is illustrated through a leukemia survival data set and a dental health data set. The proposed method will be especially useful for analyzing progression-free survival in multi-regional cancer clinical trials.
Keyphrases
- electronic health record
- clinical trial
- big data
- free survival
- public health
- systematic review
- randomized controlled trial
- mental health
- squamous cell carcinoma
- acute myeloid leukemia
- data analysis
- bone marrow
- ejection fraction
- open label
- deep learning
- young adults
- study protocol
- human health
- patient reported outcomes