Ocular macrophage origin and heterogeneity during steady state and experimental choroidal neovascularization.
Steven DrohoBenjamin R ThomsonHadijat M MakindeCarla M CudaHarris PerlmanJeremy A LavinePublished in: Journal of neuroinflammation (2020)
Macrophage origin impacts heterogeneity at steady state and after laser injury in mice. Both mice and human patients demonstrate similar macrophage subtypes. Two discrete pro-angiogenic macrophage populations exist in the human choroid. Targeting specific, pro-angiogenic macrophage subsets is a potential novel therapeutic for nAMD.
Keyphrases
- adipose tissue
- endothelial cells
- end stage renal disease
- single cell
- newly diagnosed
- ejection fraction
- induced pluripotent stem cells
- high fat diet induced
- type diabetes
- optical coherence tomography
- prognostic factors
- peritoneal dialysis
- anti inflammatory
- pluripotent stem cells
- cancer therapy
- risk assessment
- patient reported outcomes