Puppet masters of B-cell progenitor acute lymphoblastic leukemia: The preB cell receptor and the interleukin 7 receptor α.
Dennis Das GuptaMichael LohoffPublished in: European journal of immunology (2023)
B-cell progenitor acute lymphoblastic leukemia (BCP-ALL) is enriched for a preB cell phenotype, hinting at a specific vulnerability of this cell stage. Two signaling pathways via the preB cell receptor (preBCR) and the interleukin 7 receptor α (IL-7Rα) chain govern the balance between differentiation and proliferation at this stage and both receptor pathways are routinely altered in human BCP-ALL. Here, we review the immunobiology of both the preBCR as well as the IL-7Rα and analyze the human BCP-ALL spectrum in the light of these signaling complexes. Finally, we present a terminology for preBCR signaling modules that distinguishes a pro-proliferative "phase-I" module from a pro-differentiative "phase-II" module. This terminology might serve as a framework to better address shared oncogenic mechanics of preB cell stage BCP-ALL.
Keyphrases
- acute lymphoblastic leukemia
- single cell
- cell therapy
- endothelial cells
- signaling pathway
- phase ii
- stem cells
- randomized controlled trial
- allogeneic hematopoietic stem cell transplantation
- transcription factor
- mesenchymal stem cells
- open label
- acute myeloid leukemia
- oxidative stress
- induced apoptosis
- network analysis