Analysis of Drug Effects on Primary Human Coronary Artery Endothelial Cells Activated by Serum Amyloid A.

Katja Lakota D HrušovarM OgričK Mrak-PoljšakS ČučnikM TomšičBorut BožičP ŽigonS Sodin-Semrl

Published in: Mediators of inflammation (2018)

We observed marked influence of fluvastatin on lowering cytokine production in SAA-activated HCAEC. Methotrexate showed strong beneficial effects for lowering released Il-6, IL-8, and sVCAM-1. Interesting duality was observed for NSAIDs, with meloxicam exhibiting opposite-trend effects from diclofenac and etoricoxib. This represents unique insight into specific responsiveness of inflammatory-driven HCAEC relevant to atherosclerosis.

Keyphrases

endothelial cells
coronary artery
high glucose
pulmonary artery
cardiovascular disease
high dose
oxidative stress
vascular endothelial growth factor
induced pluripotent stem cells
pulmonary hypertension
pluripotent stem cells
drug induced
low dose
adverse drug
anti inflammatory drugs